Suggest Entresto for heart failure patients with persistent symptoms

December 2015

You'll hear about Entresto (en-TRESS-toh), a new drug for symptomatic heart failure with reduced ejection fraction.

It's the first "angiotensin receptor neprilysin inhibitor" (ARNI)...and combines sacubitril (sah-KYOO-bih-tril) with valsartan.

Sacubitril works by inhibiting the enzyme neprilysin. This increases vasodilation and urinary sodium loss...and enhances ARB effects.

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Table of Contents

Heart Failure Suggest Entresto for heart failure patients with persistent symptoms
Geriatrics Think of Beers Criteria as a "Warning Light" Rather Than a "Stop Sign"
Opioids More patients will need your help tapering off chronic opioids
Diabetes Diabetes patients will need your help sticking with metformin
Diabetes association between the SGLT2 inhibitor, Invokana (canagliflozin), and bone fractures
Cardiology Don't Routinely Recommend Repatha (Evolocumab) for High Cholesterol
Vitamins & Minerals Consider Supplementing Vitamin D in Kids if Diet Isn't Enough
Alcohol when to avoid alcohol with certain medications
Medication Errors Follow the Mantra, "When in Doubt, Fill the Incident Report Out"
Supplements the dangers of using dietary supplements
Asthma Spiriva Respimat (tiotropium) will be the first long-acting anticholinergic for ASTHMA